Abstract
An IKKbeta inhibitor reported to block NF-kappaB transcriptional activities in Jurkat T cells, was found to enhance NF-kappaB translocation in HUVEC cells. These studies suggested a noncanonical NF-kappaB signaling pathway independent of IKKbeta in HUVEC cells.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Combinatorial Chemistry Techniques
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Humans
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Jurkat Cells
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Leupeptins / chemistry
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Leupeptins / pharmacology
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Molecular Structure
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NF-kappa B / drug effects
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NF-kappa B / metabolism*
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Nitriles / chemistry
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Nitriles / pharmacology
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Quinazolines / chemical synthesis*
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Quinazolines / chemistry
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Quinazolines / pharmacology*
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Sulfones / chemistry
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Sulfones / pharmacology
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Sulfoxides / chemistry
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Sulfoxides / pharmacology
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Tetrazoles / chemistry
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Tetrazoles / pharmacology
Substances
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3-(4-methylphenylsulfonyl)-2-propenenitrile
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Leupeptins
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NF-kappa B
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Nitriles
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Quinazolines
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Ro 106-9920
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Sulfones
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Sulfoxides
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Tetrazoles
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benzyloxycarbonylleucyl-leucyl-leucine aldehyde